According to the World Health Organization (WHO), undesirable effects are classified according to their rate of development as follows: very common (≥ 1/10), commonly (≥1 / 100, <1/10), uncommon (≥1 / 1000, < 1/100), rare (≥1 / 10,000, <1/1000), very rare (<1/10000), not known frequency (frequency of events can not be determined on the basis of available data). on the part of the cardiovascular durabolin 100 systemoften: pronounced lowering blood pressure, a violation orthostatic regulation of vascular tone (orthostatic hypotension), syncope; rare: orthostatic hypotension, myocardial ischemia, including the development of angina attack, or myocardial infarction, cerebrovascular accident (due to a sharp drop in blood pressure in at-risk patients), tachycardia, arrhythmia, peripheral edema, palpitation, “tides” of blood to the skin of the face, rarely: the emergence or strengthening of circulatory disorders in the background stenotic vascular lesions, vasculitis; incidence is unknown: Raynaud’s syndrome. From the side of hematopoiesisuncommon: eosinophilia, rare: leucopenia, including neutropenia and agranulocytosis (neutropenia and agranulocytosis are reversible and disappear with the abolition of ACE inhibitors), anemia, thrombocytopenia, lymphadenopathy, decreased hemoglobin, the frequency is unknown: inhibition of bone marrow hematopoiesis, pancytopenia, haemolytic anemia. From the nervous system common:weakness, headache uncommon: lability mood, anxiety, nervousness, paresthesia, dizziness, sleep disturbances, insomnia, restlessness; rare: tremor, balance disorder, confusion, the frequency is not known: cerebral ischemia, including durabolin 100 stroke and transient ischemic attack, parosmiya (impaired sense of smell) . violation of psychomotor reactions, impaired concentration From the senses uncommon:visual disturbances including blurred image, taste disturbance; rare: conjunctivitis, hearing loss, tinnitus (sensation of ringing noise in the ears). The respiratory system is often: “dry “cough, bronchitis, sinusitis, shortness of breath, rarely: bronchospasm, including exacerbation of asthma, nasal congestion. From the digestive system common: inflammatory reactions in the stomach and intestines, indigestion, discomfort in the abdomen, indigestion, diarrhea, nausea, vomiting uncommon: pancreatitis, increased activity of “liver” transaminases and bilirubin concentrations of conjugate in plasma, increasing the activity of enzymes of the pancreas, intestinal angioedema, abdominal pain, gastritis, constipation, dryness of the oral mucosa; rare: glossitis; cholestatic jaundice, hepatocellular injury, the frequency is unknown: aphthous stomatitis (inflammatory reaction of the oral mucosa), acute hepatic failure, cholestatic or cytolytic hepatitis, including . fatal From the urinary tract rare: impaired renal function, including acute renal failure, increased allocation of the amount of urine, increased pre-existing proteinuria, increasing concentrations of urea and creatinine in the blood. For the skin and mucous membranes often: skin rash, in particular makulezno-papular; rare: angioedema, including fatal (laryngeal edema can cause airway obstruction leading to death), pruritus, hyperhidrosis (excessive sweating);rare: exfoliative dermatitis, urticaria, onycholysis ( detachment of the nail from the soft tissues of the finger); very rare: photosensitivity reactions, the frequency is not known: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, pemphigus (cystic rash), exacerbation of psoriasis, psoriasiform dermatitis, pemfigoidnaya or lichenoid exanthema or enanthema, alopecia . On the part of the musculoskeletal system often: muscle cramps, myalgia; rare: arthralgia. On the part of metabolism often: increase potassium in the blood; infrequently: anorexia, decreased appetite; frequency not known: reduction of sodium in the blood. On the part of the immune system frequency unknown: anaphylactic or anaphylactoid reactions, increased titers of antinuclear antibodies. On the part of the endocrine system frequency is not known: syndrome of inappropriate secretion of antidiuretic hormone (SNA ADH). reproductive system uncommon: transient impotence due to erectile dysfunction, decreased libido, frequency is durabolin 100 not known: gynaecomastia . General disorders and administration site in common: chest pain, fatigue; rare: fever; rare: asthenia.
Symptoms: excessive peripheral vasodilation with the development of significant decrease in blood pressure (BP), shock; bradycardia, a violation of water-electrolyte balance, shock, acute renal failure, stupor. Treatment: In mild cases of overdose: gastric lavage, administration of adsorbents, sodium sulfate (preferably within the first 30 min after administration). It is necessary to control the function of vital organs. In more severe cases – measures aimed at stabilizing the blood pressure: intravenous infusion of 0.9% sodium chloride solution, plasma substitutes, temporary pacemaker when resistant to drug therapy bradycardia, hemodialysis. In marked decrease in blood pressure therapy to replenish blood volume and restoration of fluid and electrolyte balance may be added to durabolin 100 the introduction of alpha-adrenergic agonists (norepinephrine, dopamine). In the case of bradycardia recommended the appointment of atropine or setting a temporary pacemaker. Blood pressure should be carefully monitored, renal function and electrolyte content in the blood serum. Experience of application of forced diuresis, alteration in urine pH, haemofiltration or dialysis for the accelerated elimination of ramipril is excreted not.Hemodialysis is indicated in cases of renal insufficiency.