After oral administration of pyrantel is poorly absorbed from the gastrointestinal tract. After administration of a single dose of 10 mg / kg pyrantel plasma concentration of 0,005-0,13 / ml for 1-3 hours. Pyrantel absorbed into the systemic circulation, durabolin 25 it is partially metabolized in the liver to N-methyl-1,3- propanediamina. 50% of the dose is excreted unchanged in the faeces, approximately 7% – with urine unchanged or as metabolites.
The main indications for use are ascariasis, hookworm, and necatoriasis enterobiosis.
– Myasthenia gravis (treatment period);
– Children under 3 years of age (the solid dosage form);
– Hypersensitivity to pyrantel and other ingredients.
Hepatic insufficiency. Pregnancy and lactation When pregnancy is used only if the expected benefit to the mother outweighs risk to the fetus. If used during lactation should stop breastfeeding.
Dosing and Administration
The drug is prescribed inside during or after eating, and dosage adjusted individually depending durabolin 25 on the age and weight of the patient. Ascariasis and Enterobiasis, and mixed infestations – a single dose of 10 mg / kg body weight.
Side effect On the part of the digestive tract and liver: decreased appetite, nausea, vomiting, diarrhea, stomach pain; rarely – increased activity of hepatic transaminases. CNS: rarely – headache, dizziness, somnolence, insomnia, weakness; in some cases – hearing impairment, hallucinations, confusion, parestenzii. Other: skin rash, fever.
The tablet should be thoroughly chewed. Ankilostomidoze: drug prescribed rate of 10 mg / kg of body weight per day for 3 days. Necatoriasis: with severe drug administered in a dose of 20 mg / kg of body weight per day for 2 days.
Overdose Treatment: gastric lavage. No specific antidote.
should not be administered simultaneously with piperazine (weakening of the action).
In an application pyrantel increases the concentration of theophylline in plasma.
After receiving pyrantel laxative is not appointed.
In enterobioze should conduct simultaneous treatment of all persons living together. After the treatment is necessary to control study of feces for the presence durabolin 25 of parasite eggs.
Careful hygiene (household cleaning and cleaning clothes for the destruction of helminth eggs is prevention of reinfection).