The drug has analgesic, antipyretic, anti-inflammatory, antispasmodic, sedative effect. Piralgin – combined formulation that combines the properties of the active ingredients. Metamizole sodium and naproxen – drugs group narcotic analgesics have antipyretic action, analgesic activity, which increases codeine (blocks the opiate receptors, stimulates nandrolone phenylpropionate side effects the antinociceptive system and changes the emotional perception of pain). Naproxen is also has a strong anti-inflammatory action.Phenobarbital has a sedative effect. Caffeine causes dilation of blood vessels in skeletal muscle, brain, heart, kidney; enhances mental and physical performance, helps to eliminate fatigue and drowsiness; raises blood pressure hypotension; gistogematicheskih increases the permeability barriers and enhances the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect.
The pharmacokinetics of
the drug’s components are well absorbed in the gastrointestinal tract. Metamizole: in the intestinal wall is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized formyl-4-amino-antipyrine and other metabolites. The level of the active metabolite binding proteins is 50-60%. The excretion of metabolites passes through the kidneys. In addition, the metabolites are excreted in breast milk.
Naproxen: bioavailability is 95%. Associated with the blood proteins. The half – 12-15 hours. Excreted in the urine primarily as metabolites (dimetilnaproksen), in small quantities – bile.
Caffeine: well absorbed in the gut, the half-life -5ch (sometimes – up to 10 hours). Write mainly kidneys as metabolites, about 10% – unchanged. Codeine: slightly bound to plasma proteins. Biotransformation in the liver (10% by demethylation proceeds nandrolone phenylpropionate side effects to morphine). Excreted kidneys (5-15% – unchanged).
Phenobarbital: bioavailability is 80%. The plasma protein binds to 50%, cross the placenta well. Biotransformed in the liver. The main metabolite does not possess pharmacological activity. Report the news, including 20-25% – unchanged.
Piralgin take at moderately expressed pain syndrome of different genesis. It is especially effective for pain in the joints, muscles, sciatica, menstrual pain, neuralgia, as well as headache, migraine, toothache. Piralgin can be used for fevers, colds and other diseases involving pain and inflammation phenomena.
: Hypersensitivity to the drug; expressed human liver or kidney; deficiency of glucose-6-phosphate dehydrogenase; gastric ulcer and duodenal ulcer in the acute stage; bronchospasm; blood diseases; State, accompanied by respiratory depression; increased intracranial pressure, head injury; acute myocardial infarction; cardiac arrhythmias; high blood pressure; glaucoma; alcohol intoxication; Children’s age – 12 years.
Pregnancy and lactation: The drug is contraindicated in pregnancy. If necessary, use during lactation is necessary to resolve the issue of termination of breastfeeding.
Dosing and Administration
The drug is taken orally, usually 1 tablet 1-3 times a day. The maximum daily dose – 4 tablets. The drug should not take more than 5 days as an analgesic without a prescription.
are possible dyspeptic disorders (nausea, vomiting, constipation), allergic skin reactions (rash, pruritus, urticaria), epigastric pain, dizziness, drowsiness, palpitations. Rarely – oppression blood (leucopenia, granulocytopenia, agranulocytosis). Chronic administration of high doses may impair liver function and kidney.
Overdosing Symptoms: nausea, vomiting, stomach pain, tachycardia, cardiac arrhythmias, weakness, drowsiness, light-headedness, respiratory depression. Treatment: induction vomiting, chrezzondovoe gastric lavage, the appointment of adsorbents (activated charcoal), symptomatic therapy aimed at maintaining vital functions .
Needed medical supervision during administration of the drug.
With caution used in patients with impaired hepatic or renal function, with gastric ulcer and duodenal ulcer in remission, the elderly, long-term alcohol history.
Using the drug for more than 5 days is necessary to monitor patterns of peripheral blood and functional state of the liver.
The drug can make it difficult to establish a diagnosis in acute pain syndrome in the abdomen.
Piralin may hinder the execution of the work, which requires a high rate of mental and physical reactions (driving vehicles, operating machinery, appliances, etc.). Patients should be made aware of the fact that long-term use of the drug without proper medical supervision may develop addiction and the formation of drug dependence. During nandrolone phenylpropionate side effects treatment Piralginom need to abstain from alcohol.
Interaction with other medicinal products
Concomitant use of the drug with other non-narcotic analgesics may lead to increased toxicity. Tricyclic antidepressants, contraceptives oral, allopurinol increase the toxicity of sodium metamizol (dipyrone), which is part of the preparation. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken action Metamizole (dipyrone). Concomitant use of sodium metamizol (dipyrone) with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the analgesic effect of the drug.